Larry Kaiser, MD, president and CEO of Philadelphia-based Temple University Health System, is leaving the role, effective Dec. 31. 
He is also stepping down as dean of Temple's Lewis Katz School of Medicine and senior executive vice president for health sciences at Temple University, both in Philadelphia.
Dr. Kaiser has led Temple University Health System since 2011, driving key changes, including the establishment of a network of ambulatory care centers. During his tenure, the medical school opened a campus in the Lehigh Valley.
Chief Restructuring Officer Stuart McLean will become acting CEO of the health system, effective Sept. 30. Until Dr. Kaiser's December departure, he will focus on supporting the health system restructuring with Mr. McLean and the president of Temple University, Richard M. Englert.
John M. Daly, emeritus dean of the Lewis Katz School of Medicine, will be the medical school's interim leader.
"It is difficult to leave a place where I have invested so much of my passion, energy and enthusiasm, but I think it is important for Temple to allow new leadership to step in and guide the restructured enterprise into its next chapter," said Dr. Kaiser. "This is the right time for me and for Temple to make this change, and I look forward to the next phase of my career."
Before joining Temple, Dr. Kaiser was president of UTHealth, the University of Texas Health Science Center at Houston.
A thoracic surgeon, he has served on the faculty at Memorial Sloan-Kettering Cancer Center in New York City and the Washington University School of Medicine in St. Louis.
"Larry Kaiser is an outstanding person and leader," said Scott Becker, publisher of Becker's Hospital Review. "I have loved working with Dr Kaiser."