Mayo Clinic has developed a screening procedure that could dramatically increase testing for Lynch syndrome, a hereditary genetic disorder that raises cancer risk, particularly for colorectal cancer, according to a hospital news release.
Mayo Clinic researchers have developed and tested a protocol that could raise the level of testing for Lynch syndrome to nearly 90 percent. In 2003, the researchers began testing all newly diagnosed colorectal cancers in patients under 50. Biopsies of the cancers were sent to pathologists who conducted Microsatellite Instability testing, which looks for certain mutations in genes that repair DNA by testing 10 different DNA markers for irregularities. Patients categorized in the "high" group for microsatellite instability were offered additional testing for Lynch syndrome and genetic counseling.
Over a five-year study period, 210 of 258 newly diagnosed patients under age 50 who underwent colorectal cancer surgery had the MSI testing. Of those, 13 percent had MSI-H tumors. Overall, 88 percent of the high-risk group had tests, and the protocol caught 11 percent of MSI-H tumors that would have otherwise been missed.
Read the hospital news release about Mayo Clinic's new screening procedure for Lynch syndrome.
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Mayo Clinic researchers have developed and tested a protocol that could raise the level of testing for Lynch syndrome to nearly 90 percent. In 2003, the researchers began testing all newly diagnosed colorectal cancers in patients under 50. Biopsies of the cancers were sent to pathologists who conducted Microsatellite Instability testing, which looks for certain mutations in genes that repair DNA by testing 10 different DNA markers for irregularities. Patients categorized in the "high" group for microsatellite instability were offered additional testing for Lynch syndrome and genetic counseling.
Over a five-year study period, 210 of 258 newly diagnosed patients under age 50 who underwent colorectal cancer surgery had the MSI testing. Of those, 13 percent had MSI-H tumors. Overall, 88 percent of the high-risk group had tests, and the protocol caught 11 percent of MSI-H tumors that would have otherwise been missed.
Read the hospital news release about Mayo Clinic's new screening procedure for Lynch syndrome.
Related Articles about Becker's Top 50 Hospitals:
Cleveland Clinic Names Dr. Mark Schickendantz Director of the Center for Sports Health
Massachusetts General Study Shows Mild Obesity May Improve Survival in Lou Gehrig's Disease Patients
Pennsylvania's Lehigh Valley, Phoebe Ministries Form Teleneurology Partnership