In 2022, the FDA approved 96 first-time generic drugs.
Here's the list of the generics and their treatment use, in order of approval date:
Note: Repeats are abbreviated new drug applications from different drugmakers.
- Pirfenidone capsules — For the treatment of idiopathic pulmonary fibrosis
- Carbidopa, levodopa and entacapone tablets — For the treatment of Parkinson's disease
- Pirfenidone tablets — For the treatment of idiopathic pulmonary fibrosis
- Pirfenidone tablets — For the treatment of idiopathic pulmonary fibrosis
- Sofosbuvir tablets — For the treatment of adult patients with genotype 1, 2, 3 or 4 chronic HCV infection without cirrhosis or with compensated cirrhosis as a component of a combination antiviral treatment regimen
- Dextroamphetamine saccharate, amphetamine aspartate monohydrate, dextroamphetamine sulfate, amphetamine sulfate extended release capsules — For the treatment of attention-deficit hyperactivity disorder in patients 13 years and older
- Brimonidine tartrate ophthalmic solution, 0.15% — For the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension
- Cyclosporine ophthalmic emulsion, 0.05% — To increase tear production in patients whose tear production is presumed to be suppressed due to ocular inflammation associated with keratoconjunctivitis sicca
- Maraviroc tablets — For the treatment of only CCR5-tropic HIV-1 infection in adults and pediatric patients weighing at least 2 kg
- Digoxin tablets — For the treatment of mild to moderate heart failure in adults
- Nalmefene hydrochloride injection — For the complete or partial reversal of opioid drug effects, including respiratory depression, induced by either natural or synthetic opioids; for management of known or suspected opioid overdose
- Tolvaptan tablets — Treatment of clinically significant hypervolemic and euvolemic hyponatremia including patients with heart failure and Syndrome of Inappropriate Antidiuretic Hormone
- Dapagliflozin tablets — As an adjunct to diet and exercise to improve glycemic control
- Apomorphine hydrochloride injection, single-patient-use glass cartridge for use with a reusable pen injector — For the acute, intermittent treatment of hypomobility, "off" episodes associated with advanced Parkinson's disease
- Doxylamine succinate and pyridoxine hydrochloride extended release tablets — For the treatment of nausea and vomiting of pregnancy in women who do not respond to conservative management
- Methylphenidate transdermal system — For the treatment of attention-deficit/hyperactivity disorder (ADHD)
- Breyna (budesonide and formoterol fumarate dihydrate) inhalation aerosol — For the treatment of asthma in patients 6 years and older and for the maintenance treatment of airflow obstruction and reducing exacerbations in patients with chronic obstructive pulmonary disease (COPD) including chronic bronchitis and/or emphysema
- Lacosamide tablets — Treatment of partial-onset seizures in patients 4 years and older
- Lacosamide tablets — Treatment of partial-onset seizures in patients 4 years and older
- Lacosamide tablets — Treatment of partial-onset seizures in patients 4 years and older
- Lacosamide tablets — Treatment of partial-onset seizures in patients 4 years and older
- Lacosamide tablets — Treatment of partial-onset seizures in patients 4 years and older
- Lacosamide tablets — Treatment of partial-onset seizures in patients 4 years and older
- Lacosamide tablets — Treatment of partial-onset seizures in patients 4 years and older
- Lacosamide tablets — Treatment of partial-onset seizures in patients 4 years and older
- Lactated ringer's and 5% dextrose injection — For the parenteral replacement of extracellular losses of fluid and electrolytes, with or without minimal carbohydrate calories, as required by the clinical condition of the patient
- Sodium phosphates injection — As a source of phosphorus, for addition to large volume intravenous fluids, to prevent or correct hypophosphatemia in patients with restricted or no oral intake
- Brimonidine tartrate and timolol maleate ophthalmic solution — For the reduction of elevated intraocular pressure in patients with ocular hypertension who require adjunctive or replacement therapy due to inadequately controlled IOP
- Isosorbide dinitrate and hydralazine hydrochloride tablets — For the treatment of heart failure as an adjunct therapy to standard therapy in self-identified Black patients to improve survival, prolong time to hospitalization for heart failure and to improve patient-reported functional status
- Lacosamide injection — For the treatment of partial-onset seizures in patients 17 years and older
- Cysteine hydrochloride injection — Indicated to meet the nutritional requirements of newborn infants requiring total parenteral nutrition; and of adult and pediatric patients with severe liver disease who may have impaired enzymatic processes and require TPN
- Regadenoson injection — Indicated for radionuclide myocardial perfusion imaging in patients unable to undergo adequate exercise stress
- Regadenoson injection — Indicated for radionuclide myocardial perfusion imaging in patients unable to undergo adequate exercise stress
- Regadenoson injection — Indicated for radionuclide myocardial perfusion imaging in patients unable to undergo adequate exercise stress
- Regadenoson injection — Indicated for radionuclide myocardial perfusion imaging in patients unable to undergo adequate exercise stress
- Phytonadione injectable emulsion — For the treatment of certain coagulation disorders which are due to faulty formation of factors II, VII, IX and X when caused by vitamin K deficiency or interference with vitamin K activity
- Phytonadione injectable emulsion — For the treatment of certain coagulation disorders which are due to faulty formation of factors II, VII, IX and X when caused by vitamin K deficiency or interference with vitamin K activity
- Bexarotene Gel — For the topical treatment of cutaneous lesions in patients with CTCL (Stage IA and IB) who have refractory or persistent disease after other therapies or who have not tolerated other therapies
- Bortezomib for injection — For the treatment of adult patients with multiple myeloma; treatment of adult patients with mantle cell lymphoma
- Bortezomib for injection — For the treatment of adult patients with multiple myeloma; treatment of adult patients with mantle cell lymphoma
- Bortezomib for injection — For the treatment of adult patients with multiple myeloma; treatment of adult patients with mantle cell lymphoma
- Bortezomib for injection — For the treatment of adult patients with multiple myeloma; treatment of adult patients with mantle cell lymphoma
- Bortezomib for injection — For the treatment of adult patients with multiple myeloma; treatment of adult patients with mantle cell lymphoma
- Bortezomib for injection — For the treatment of adult patients with multiple myeloma; treatment of adult patients with mantle cell lymphoma
- Bortezomib for injection — For the treatment of adult patients with multiple myeloma; treatment of adult patients with mantle cell lymphoma
- Bortezomib for injection — For the treatment of adult patients with multiple myeloma; treatment of adult patients with mantle cell lymphoma
- Zinc sulfate injection — As a source of zinc for parenteral nutrition when oral or enteral nutrition is not possible, insufficient or contraindicated
- Diclofenac topical solution — For the treatment of the pain of osteoarthritis of the knee
- Mesalamine extended release capsules — For the induction of remission and for the treatment of adult patients with mildly to moderately active ulcerative colitis
- Estradiol and progesterone capsules — For the treatment of moderate to severe vasomotor symptoms due to menopause
- Lacosamide oral solution — For the treatment of partial-onset seizures in patients 4 years and older
- Iodixanol injection — Radiographic contrast agent indicated for certain intra-arterial and intravenous procedures
- Pemetrexed for injection — For the treatment of non-squamous non-small cell lung cancer and mesothelioma
- Pemetrexed for injection — For the treatment of non-squamous non-small cell lung cancer and mesothelioma
- Pemetrexed for injection — For the treatment of non-squamous non-small cell lung cancer and mesothelioma
- Pemetrexed for injection — For the treatment of non-squamous non-small cell lung cancer and mesothelioma
- Pemetrexed for injection — For the treatment of non-squamous non-small cell lung cancer and mesothelioma
- Pemetrexed for injection — For the treatment of non-squamous non-small cell lung cancer and mesothelioma
- Pemetrexed for injection — For the treatment of non-squamous non-small cell lung cancer and mesothelioma
- Pemetrexed for injection — For the treatment of non-squamous non-small cell lung cancer and mesothelioma
- Pemetrexed for injection — For the treatment of non-squamous non-small cell lung cancer and mesothelioma
- Pemetrexed for injection — For the treatment of non-squamous non-small cell lung cancer and mesothelioma
- Pemetrexed for injection — For the treatment of non-squamous non-small cell lung cancer and mesothelioma
- Pemetrexed for injection — For the treatment of non-squamous non-small cell lung cancer and mesothelioma
- Pemetrexed for injection — For the treatment of non-squamous non-small cell lung cancer and mesothelioma
- Pemetrexed for injection — For the treatment of non-squamous non-small cell lung cancer and mesothelioma
- Posaconazole injection — For the prophylaxis of invasive Aspergillus and Candida infections in patients who are at high risk of developing these infections due to being severely immunocompromised
- Atropine Sulfate injection — For the temporary blockade of severe or life threatening muscarinic effects
- Multiple Electrolytes injection — Indicated as a source of water and electrolytes or as an alkalinizing agent
- Brivaracetam tablets — For the treatment of partial-onset seizures in patients 4 years and older
- Ibuprofen oral suspension (OTC) — For the temporary reduction of fever, relief minor aches and pains due to the common cold, flu, headaches and toothaches
- Cabazitaxel injection — In combination with prednisone for the treatment of patients with metastatic castration-resistant prostate cancer previously treated with a docetaxel-containing treatment regimen
- Abiraterone acetate tablets — In combination with methylprednisolone for the treatment of patients with metastatic castration-resistant prostate cancer
- Multiple electrolytes injection — Indicated as a source of water and electrolytes or as an alkalinizing agent
- Empagliflozin and metformin hydrochloride tablets — As an adjunct to diet and exercise to improve glycemic control in adults with Type 2 diabetes mellitus; to reduce the risk of cardiovascular death in adults with Type 2 diabetes mellitus and established cardiovascular disease
- Fenoprofen calcium capsules — For the relief of mild to moderate pain in adults; relief of the signs and symptoms of rheumatoid arthritis; relief of the signs and symptoms of osteoarthritis
- Sodium picosulfate, magnesium oxide, and anhydrous citric acid for oral solution — For the cleansing of the colon as a preparation for colonoscopy in adults and pediatric patients ages 9 years and older
- Pirfenidone tablets — For the treatment of idiopathic pulmonary fibrosis
- Azilsartan medoxomil tablets — For the treatment of hypertension to lower blood pressure
- Minocycline for injection — For the treatment of infections caused by certain Gram-negative and Gram-positive bacteria, and others, when bacteriologic testing indicates appropriate susceptibility
- Empagliflozin tablets — Indicated as an adjunct to diet and exercise to improve glycemic control in adults with Type 2 diabetes mellitus
- Estradiol Gel, 0.1% — For the treatment of moderate to severe vasomotor symptoms due to menopause
- Brexpiprazole tablets — For use as an adjunctive therapy to antidepressants for the treatment of major depressive disorder in adults; treatment of schizophrenia in adults
- Cetrorelix acetate for injection — For the inhibition of premature LH surges in women undergoing controlled ovarian stimulation
- Rufinamide tablets — For the adjunctive treatment of seizures associated with Lennox-Gastaut Syndrome in pediatric patients 1 year and older and in adults
- Sodium nitroprusside in 0.9% sodium chloride injection — For the immediate reduction of blood pressure; for producing controlled hypotension to reduce bleeding during surgery; for the treatment of acute heart failure to reduce left ventricular end-diastolic pressure, pulmonary capillary wedge pressure, peripheral vascular resistance and mean arterial blood pressure
- Riociguat tablets — For the treatment of adults with persistent/recurrent Chronic Thromboembolic Pulmonary Hypertension after surgical treatment or inoperable CTEPH to improve exercise capacity and WHO functional class; for the treatment of pulmonary arterial hypertension to improve exercise capacity, improve WHO functional class and to delay clinical worsening
- Roflumilast tablets — A treatment to reduce the risk of COPD exacerbations in patients with severe COPD associated with chronic bronchitis and a history of exacerbations
- Cariprazine capsules — For the treatment of schizophrenia in adults; for the acute treatment of manic or mixed episodes associated with bipolar I disorder in adults;for the treatment of depressive episodes associated with bipolar I disorder (bipolar depression) in adults
- Tazarotene gel, 0.05% — For the topical treatment of plaque psoriasis of up to 20% body surface area involvement
- Tazarotene gel, 0.1% — For the topical treatment of plaque psoriasis of up to 20% body surface area involvement; for the topical treatment of mild to moderate facial acne vulgaris
- Vyduo (nebivolol and valsartan) tablets — For the treatment of hypertension, to lower blood pressure
- Gefitinib tablets — For the first-line treatment of patients with metastatic non-small cell lung cancer whose tumors have epidermal growth factor receptor exon 19 deletions or exon 21 substitution mutations
- Darunavir tablets — For the treatment of HIV-1 infection in adult and pediatric patients 3 years and older
- Mirabegron extended release tablets — For the treatment of overactive bladder in adult patients with symptoms of urge urinary incontinence, urgency, and urinary frequency
- Cupric chloride injection — For use as a supplement to intravenous solutions given for total parenteral nutrition