Researchers tested a more direct measure of anesthetic activity to increase accuracy of the model brain uptake, according to a study in the September issue of Anesthesia & Analgesia.
Previous modeling of kinetics of uptake and elimination of anesthetic drugs use the electroencephalogram, which lags brain activity because of time to acquire a signal.
The researchers studied 20 subjects at 30 percent nitrous oxide and monitored the digit symbol substitution test. They determined in subanesthetic concentrations, nitrous oxide has rapid onset and offset with a half time of two minutes. This is less than the values expected during anesthesia using processed electroencephalogram.
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Previous modeling of kinetics of uptake and elimination of anesthetic drugs use the electroencephalogram, which lags brain activity because of time to acquire a signal.
The researchers studied 20 subjects at 30 percent nitrous oxide and monitored the digit symbol substitution test. They determined in subanesthetic concentrations, nitrous oxide has rapid onset and offset with a half time of two minutes. This is less than the values expected during anesthesia using processed electroencephalogram.
More Articles on Anesthesia:
Anesthesia Pump with ONDEMAND Bolus Button Recalled by FDA
Anesthesiologist Dr. Luke Stoltzfus Joins St. Luke's Anesthesia Associates
Dr. Steven Sheinman Appointed to Sheridan Healthcare's New Ambulatory Anesthesia Position