Immediate-Release Opioids Can Supplement Transdermal Buprenorphine

At a PAINWeek 2012 presentation investigators reported that immediate-release opioids are acceptable to use as supplemental analgesia in certain situations, according to the Monthly Prescribing Reference.

Studies have shown immediate-release opioids can be used supplementally when transdermal buprenorphine is being used to manage moderate-to-severe chronic pain.

The study cleared up confusion as whether or not immediate-release opioids would properly function with buprenorphine, which may displace or prevent competing mu-opioid agonists from binding.

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