In 2023, Mark Cuban Cost Plus Drug Co. began selling two generic medications cheaper than their branded versions by more than $10,000.
The two drugs are fingolimod hydrochloride, a multiple sclerosis medication, and penicillamine, which treats rheumatoid arthritis, metal toxicity and cystinuria. Fingolimod HCl is more than $13,000 and penicillamine is about $11,200 on average, according to Cost Plus Drugs' website.
Through Mark Cuban's online pharmacy — which sells generics alongside a $5 pharmacy dispensing fee, $5 shipping fee and a 15 percent profit margin — these two medications are about 98 percent less expensive than the retail price.
Here are the top 50 medications with the biggest price cuts sold at Cost Plus Drugs:
1. Fingolimod HCl (Generic for Gilenya)
Retail price: $13,067.14
MCCPDC price: $295.03
Savings: $12,772.11
2. Penicillamine (Generic for Cuprimine)
Retail price: $11,192.10
MCCPDC price: $135.20
Savings: $11,056.90
3. Tolvaptan (Generic for Samsca)
Retail price: $9,039.90
MCCPDC price: $1,902.50
Savings: $7,137.40
4. Teriflunomide (Generic for Aubagio)
Retail price: $3,552.30
MCCPDC price: $12.80
Savings: $3,539.50
5. Temozolomide (Generic for Temodar)
Retail price: $3,363.60
MCCPDC price: $313.70
Savings: $3,049.90
6. Imatinib (Generic for Gleevec)
Retail price: $2,502.50
MCCPDC price: $13.40
Savings: $2,489.10
7. Deferasirox (Generic for Jadenu)
Retail price: $2,332.80
MCCPDC price: $17.00
Savings: $2,315.80
8. Aprepitant (Generic for Emend)
Retail price: $2,691.90
MCCPDC price: $524.60
Savings: $2,167.30
9. Dimethyl fumarate (Generic for Tecfidera)
Retail price: $2,176.06
MCCPDC price: $14.20
Savings: $2,161.86
10. Omeprazole-sodium bicarbonate (Generic for Zegerid)
Retail price: $2,072.88
MCCPDC price: $22.10
Savings: $2,050.78
11. Drospirenone ethinyl estradiol (Generic for Yasmin, Syeda, Ocella, Zarah)
Retail price: $1,917.00
MCCPDC price: $11.15
Savings: $1,905.85
12. Emtricitabine-tenofovir DF (Generic for Truvada)
Retail price: $1,847.41
MCCPDC price: $17.42
Savings: $1,829.99
13. Trientine HCl (Generic for Syprine)
Retail price: $1,929.90
MCCPDC price: $108.50
Savings: $1,821.40
14. Valganciclovir (Generic for Valcyte)
Retail price: $1,750.43
MCCPDC price: $65.60
Savings: $1,684.83
15. Erlotinib HCl (Generic for Tarceva)
Retail price: $1,665.30
MCCPDC price: $64.40
Savings: $1,600.90
16. Linezolid (Generic for Zyvox)
Retail price: $1,612.20
MCCPDC price: $34.40
Savings: $1,577.80
17. Posaconazole delayed-release (Generic for Noxafil)
Retail price: $1,643.10
MCCPDC price: $173.60
Savings: $1,469.50
18. Tavaborole (Generic for Kerydin)
Retail price: $1,496.86
MCCPDC price: $101.11
Savings: $1,395.75
19. Dalfampridine ER (Generic for Ampyra)
Retail price: $1,394.30
MCCPDC price: $13.40
Savings: $1,380.90
20. Ethacrynic acid (Generic for Edecrin)
Retail price: $1,266.00
MCCPDC price: $29.00
Savings: $1,237.00
21. Abiraterone acetate (Generic for Zytiga)
Retail price: $1,093.20
MCCPDC price: $35.60
Savings: $1,057.60
22. Cyclobenzaprine extended-release (Generic for Amrix)
Retail price: $1,094.33
MCCPDC price: $55.10
Savings: $1,039.23
23. Abacavir/Lamivudine (Generic for Epzicom)
Retail price: $1,096.10
MCCPDC price: $73.40
Savings: $1,022.70
24. Vardenafil HCl (Generic for Levitra)
Retail price: $1,167.90
MCCPDC price: $200.30
Savings: $967.60
25. Entecavir (Generic for Baraclude)
Retail price: $995.75
MCCPDC price: $28.70
Savings: $967.05
26. Flucytosine (Generic for Ancobon)
Retail price: $1,181.63
MCCPDC price: $267.80
Savings: $913.83
27. Sirolimus oral solution (Generic for Rapamune oral solution)
Retail price: $1,080.43
MCCPDC price: $223.08
Savings: $857.35
28. Doxycycline hyclate (Generic for Acticlate)
Retail price: $843.32
MCCPDC price: $17.90
Savings: $825.42
29. Diclofenac sodium (Generic for Voltaren-XR)
Retail price: $853.20
MCCPDC price: $37.88
Savings: $815.32
30. Cinacalcet HCl (Generic for Sensipar)
Retail price: $824.59
MCCPDC price: $13.40
Savings: $811.19
31. Lurasidone HCl (Generic for Latuda)
Retail price: $763.80
MCCPDC price: $11.00
Savings: $752.80
32. Tenofovir disoproxil fumarate (Generic for Viread)
Retail price: $771.30
MCCPDC price: $19.70
Savings: $751.60
33. Mesalamine (Generic for Canasa)
Retail price: $766.80
MCCPDC price: $28.70
Savings: $738.10
34. Aripiprazole (Generic for Abilify)
Retail price: $677.80
MCCPDC price: $8.00
Savings: $669.80
35. Vancomycin (Generic for Vancocin HCl)
Retail price: $679.04
MCCPDC price: $34.10
Savings: $644.94
36. Granisetron HCl (Generic for Kytril)
Retail price: $643.80
MCCPDC price: $29.60
Savings: $614.20
37. Atovaquone (Generic for Mepron)
Retail price: $704.38
MCCPDC price: $111.51
Savings: $592.87
38. Clomipramine HCl (Generic for Anafranil)
Retail price: $599.40
MCCPDC price: $8.90
Savings: $590.50
39. Paliperidone extended-release (Generic for Invega)
Retail price: $635.10
MCCPDC price: $93.50
Savings: $541.60
40. Metformin extended-release (Generic for Fortamet)
Retail price: $564.47
MCCPDC price: $48.20
Savings: $516.27
41. Moxifloxacin HCl (Generic for Avelox)
Retail price: $491.10
MCCPDC price: $24.80
Savings: $466.30
42. Droxidopa (Generic for Northera)
Retail price: $483.90
MCCPDC price: $20.30
Savings: $463.60
43. Invokamet (canagliflozin-metformin HCl)
Retail price: $706.63
MCCPDC price: $245.92
Savings: $460.71
44. Estradiol vaginal estrogen tablet insert (Generic for Vagifem)
Retail price: $569.07
MCCPDC price: $113.90
Savings: $455.17
45. Invokamet extended-release (canagliflozin-metformin HCl)
Retail price: $680.50
MCCPDC price: $245.92
Savings: $434.58
46. Invokana (canagliflozin)
Retail price: $676.14
MCCPDC price: $245.92
Savings: $430.22
47. Yusimry (adalimumab-aqvh)
Retail price: $995.00
MCCPDC price: $574.25
Savings: $420.75
48. Albendazole (Generic for Albenza)
Retail price: $437.68
MCCPDC price: $35.00
Savings: $402.68
49. Riluzole (Generic for Rilutek)
Retail price: $396.90
MCCPDC price: $10.10
Savings: $386.80
50. Roflumilast (Generic for Daliresp)
Retail price: $392.10
MCCPDC price: $19.40
Savings: $372.70