50 drugs at Mark Cuban's pharmacy with biggest cost reductions

In 2023, Mark Cuban Cost Plus Drug Co. began selling two generic medications cheaper than their branded versions by more than $10,000. 

The two drugs are fingolimod hydrochloride, a multiple sclerosis medication, and penicillamine, which treats rheumatoid arthritis, metal toxicity and cystinuria. Fingolimod HCl is more than $13,000 and penicillamine is about $11,200 on average, according to Cost Plus Drugs' website. 

Through Mark Cuban's online pharmacy — which sells generics alongside a $5 pharmacy dispensing fee, $5 shipping fee and a 15 percent profit margin — these two medications are about 98 percent less expensive than the retail price. 

Here are the top 50 medications with the biggest price cuts sold at Cost Plus Drugs:

1. Fingolimod HCl (Generic for Gilenya)

Retail price: $13,067.14

MCCPDC price: $295.03

Savings: $12,772.11

2. Penicillamine (Generic for Cuprimine)

Retail price: $11,192.10

MCCPDC price: $135.20

Savings: $11,056.90

3. Tolvaptan (Generic for Samsca)

Retail price: $9,039.90

MCCPDC price: $1,902.50

Savings: $7,137.40

4. Teriflunomide (Generic for Aubagio)

Retail price: $3,552.30

MCCPDC price: $12.80

Savings: $3,539.50

5. Temozolomide (Generic for Temodar)

Retail price: $3,363.60

MCCPDC price: $313.70

Savings: $3,049.90

6. Imatinib (Generic for Gleevec)

Retail price: $2,502.50

MCCPDC price: $13.40

Savings: $2,489.10

7. Deferasirox (Generic for Jadenu)

Retail price: $2,332.80

MCCPDC price: $17.00

Savings: $2,315.80

8. Aprepitant (Generic for Emend)

Retail price: $2,691.90

MCCPDC price: $524.60

Savings: $2,167.30

9. Dimethyl fumarate (Generic for Tecfidera)

Retail price: $2,176.06

MCCPDC price: $14.20

Savings: $2,161.86

10. Omeprazole-sodium bicarbonate (Generic for Zegerid)

Retail price: $2,072.88

MCCPDC price: $22.10

Savings: $2,050.78

11. Drospirenone ethinyl estradiol (Generic for Yasmin, Syeda, Ocella, Zarah)

Retail price: $1,917.00

MCCPDC price: $11.15

Savings: $1,905.85

12. Emtricitabine-tenofovir DF (Generic for Truvada)

Retail price: $1,847.41

MCCPDC price: $17.42

Savings: $1,829.99

13. Trientine HCl (Generic for Syprine)

Retail price: $1,929.90

MCCPDC price: $108.50

Savings: $1,821.40

14. Valganciclovir (Generic for Valcyte)

Retail price: $1,750.43

MCCPDC price: $65.60

Savings: $1,684.83

15. Erlotinib HCl (Generic for Tarceva)

Retail price: $1,665.30

MCCPDC price: $64.40

Savings: $1,600.90

16. Linezolid (Generic for Zyvox)

Retail price: $1,612.20

MCCPDC price: $34.40

Savings: $1,577.80

17. Posaconazole delayed-release (Generic for Noxafil)

Retail price: $1,643.10

MCCPDC price: $173.60

Savings: $1,469.50

18. Tavaborole (Generic for Kerydin)

Retail price: $1,496.86

MCCPDC price: $101.11

Savings: $1,395.75

19. Dalfampridine ER (Generic for Ampyra)

Retail price: $1,394.30

MCCPDC price: $13.40

Savings: $1,380.90

20. Ethacrynic acid (Generic for Edecrin)

Retail price: $1,266.00

MCCPDC price: $29.00

Savings: $1,237.00

21. Abiraterone acetate (Generic for Zytiga)

Retail price: $1,093.20

MCCPDC price: $35.60

Savings: $1,057.60

22. Cyclobenzaprine extended-release (Generic for Amrix)

Retail price: $1,094.33

MCCPDC price: $55.10

Savings: $1,039.23

23. Abacavir/Lamivudine (Generic for Epzicom)

Retail price: $1,096.10

MCCPDC price: $73.40

Savings: $1,022.70

24. Vardenafil HCl (Generic for Levitra)

Retail price: $1,167.90

MCCPDC price: $200.30

Savings: $967.60

25. Entecavir (Generic for Baraclude)

Retail price: $995.75

MCCPDC price: $28.70

Savings: $967.05

26. Flucytosine (Generic for Ancobon)

Retail price: $1,181.63

MCCPDC price: $267.80

Savings: $913.83

27. Sirolimus oral solution (Generic for Rapamune oral solution)

Retail price: $1,080.43

MCCPDC price: $223.08

Savings: $857.35

28. Doxycycline hyclate (Generic for Acticlate)

Retail price: $843.32

MCCPDC price: $17.90

Savings: $825.42

29. Diclofenac sodium (Generic for Voltaren-XR)

Retail price: $853.20

MCCPDC price: $37.88

Savings: $815.32

30. Cinacalcet HCl (Generic for Sensipar)

Retail price: $824.59

MCCPDC price: $13.40

Savings: $811.19

31. Lurasidone HCl (Generic for Latuda)

Retail price: $763.80

MCCPDC price: $11.00

Savings: $752.80

32. Tenofovir disoproxil fumarate (Generic for Viread)

Retail price: $771.30

MCCPDC price: $19.70

Savings: $751.60

33. Mesalamine (Generic for Canasa)

Retail price: $766.80

MCCPDC price: $28.70

Savings: $738.10

34. Aripiprazole (Generic for Abilify)

Retail price: $677.80

MCCPDC price: $8.00

Savings: $669.80

35. Vancomycin (Generic for Vancocin HCl)

Retail price: $679.04

MCCPDC price: $34.10

Savings: $644.94

36. Granisetron HCl (Generic for Kytril)

Retail price: $643.80

MCCPDC price: $29.60

Savings: $614.20

37. Atovaquone (Generic for Mepron)

Retail price: $704.38

MCCPDC price: $111.51

Savings: $592.87

38. Clomipramine HCl (Generic for Anafranil)

Retail price: $599.40

MCCPDC price: $8.90

Savings: $590.50

39. Paliperidone extended-release (Generic for Invega)

Retail price: $635.10

MCCPDC price: $93.50

Savings: $541.60

40. Metformin extended-release (Generic for Fortamet)

Retail price: $564.47

MCCPDC price: $48.20

Savings: $516.27

41. Moxifloxacin HCl (Generic for Avelox)

Retail price: $491.10

MCCPDC price: $24.80

Savings: $466.30

42. Droxidopa (Generic for Northera)

Retail price: $483.90

MCCPDC price: $20.30

Savings: $463.60

43. Invokamet (canagliflozin-metformin HCl)

Retail price: $706.63

MCCPDC price: $245.92

Savings: $460.71

44. Estradiol vaginal estrogen tablet insert (Generic for Vagifem)

Retail price: $569.07

MCCPDC price: $113.90

Savings: $455.17

45. Invokamet extended-release (canagliflozin-metformin HCl)

Retail price: $680.50

MCCPDC price: $245.92

Savings: $434.58

46. Invokana (canagliflozin)

Retail price: $676.14

MCCPDC price: $245.92

Savings: $430.22

47. Yusimry (adalimumab-aqvh)

Retail price: $995.00

MCCPDC price: $574.25

Savings: $420.75

48. Albendazole (Generic for Albenza)

Retail price: $437.68

MCCPDC price: $35.00

Savings: $402.68

49. Riluzole (Generic for Rilutek)

Retail price: $396.90

MCCPDC price: $10.10

Savings: $386.80

50. Roflumilast (Generic for Daliresp)

Retail price: $392.10

MCCPDC price: $19.40

Savings: $372.70

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