4 CAR-T drug trials that have reported patient deaths

Since July, four clinical trials testing various CAR-T therapies have reported patient deaths: 

  1. Allogene reports patient death tied to its CAR-T drug
    Allogene Therapeutics said that one of its patients in a clinical trial for its multiple myeloma CAR-T drug died of fungal pneumonia.

  2. Patient death tied to CRISPR Therapeutics' CAR-T therapy
    An off-the-shelf CAR-T cell therapy being developed by CRISPR Therapeutics saw positive results in some patients with advanced B-cell lymphoma, but was also tied to a patient's death.

  3. FDA halts California drugmaker's CAR-T trial after patient death
    The FDA halted San Diego-based drugmaker Poseida Therapeutics' clinical trial of a CAR-T therapy after a patient died.

  4. FDA puts clinical hold on Cellectis CAR-T trial after patient dies of cardiac arrest
    The FDA put a clinical hold on French drugmaker Cellectis' trial for its off-the-shelf CAR-T therapy after a patient died of cardiac arrest.

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