Orexinergic neurons are inhibited by propofol anesthesia and the orexin signals are involved in arousal regulation from propofol, according to an article in Anesthesia & Analgesia.
Previous studies have shown that activities of orexinergic neurons were inhibited by isoflurane and sevoflurane and the microinjection of orexin facilitated the emergence from volatile anesthesia.
A study was conducted with rats infused with propofol. The loss and return of the righting reflex time were recorded. As a result, the propofol inhibited orexinergic neuron activity.
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Previous studies have shown that activities of orexinergic neurons were inhibited by isoflurane and sevoflurane and the microinjection of orexin facilitated the emergence from volatile anesthesia.
A study was conducted with rats infused with propofol. The loss and return of the righting reflex time were recorded. As a result, the propofol inhibited orexinergic neuron activity.
More Articles on Anesthesia:
80% Perioperative Inspiratory Oxygen Increased Death, Did Not Reduce Infection
Deaths Related to Anesthesia in Developing Countries Remain High
Palms West Hospital Names Dr. Dan Rogers as Chief of Pediatric Anesthesiology