A paper published by the Journal of Neuroinflammation reported a key immune system component could be blocked to make morphine treatment more effective by blocking its frequent painful side effects, according to Health Canal.
The writers reported the increased sensitivity to pain following morphine is due to the activation of an immune system receptor, TLR4, designed to detect harmful bacteria.
The study also found when morphine is metabolized in a patient's body, one metabolite, M6G, can enter the nervous system and relieve pain, but another metabolite, M3G, has no pain-relieving role.
One of the findings was if morphine could be administered along with a molecule to inhibit TLR4, then the unwanted pain could be reduced.
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The writers reported the increased sensitivity to pain following morphine is due to the activation of an immune system receptor, TLR4, designed to detect harmful bacteria.
The study also found when morphine is metabolized in a patient's body, one metabolite, M6G, can enter the nervous system and relieve pain, but another metabolite, M3G, has no pain-relieving role.
One of the findings was if morphine could be administered along with a molecule to inhibit TLR4, then the unwanted pain could be reduced.
More Articles on Anesthesia:
First Grad Completes TeamHealth Anesthesia Management Fellowship
Colorado Court Says CRNAs Can Administer Anesthesia
Somnia Releases White Paper on Anesthesia's Role in Perioperative Management