Study: Lethal Dose of Bupivacaine Higher for Rats 2 vs. 16 Weeks Old

The lethal dose for racemic bupivacaine was higher for two-week-old rats than for 16-week-old rats, according to a study published in Anesthesia & Analgesia.

Researchers infused Wistar rats with RS(±)-bupivacaine and S(−)-bupivacaine and tested cardiac electrical activity, cardiac muscle contraction and Ca2+ regulation. They found that the lethal dose of bupivacaine and strength of muscle twitches were higher in 2-week-old rats compared to 16-week-old rats. In addition, 2-week-old rats had a higher increase in Ca2+ release from the sarcoplasmic reticulum preactivated with caffeine than did their older counterparts.

The authors suggest that different mechanisms for intracellular SR Ca2+ regulation in younger rats may partially account for their decreased susceptibility to cardiodepression from bupivacaine.

Read the Anesthesia & Analgesia abstract on bupivacaine-induced cardiotoxicity at different ages.

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