Study: Dreaming in Sedation More Common With Propofol Versus Midazolam

Dreaming is almost five times more common with propofol infusion than with midazolam in patients receiving spinal anesthesia with deep sedation, according to a study published in the April 2011 issue of Anesthesia & Analgesia.

The study randomly assigned 220 adult patients to two groups and gave the patients IV infusion of propofol or midazolam for deep sedation during spinal anesthesia. Patients were interviewed on emergence from anesthesia and 30 minutes later to determine the incidence, content and nature of their dreams. The researchers also evaluated patient satisfaction with the sedation post-operatively.

Of the 215 patients included in the final analysis, the proportion of dreamers was almost 40 percent in the propofol group and 12 percent in the midazolam group. Dreams of the propofol patients were more memorable and visually vivid than the midazolam patients, and the majority of dreams were simple, pleasant ruminations about everyday life.

The study found that type of sedation did not affect patient satisfaction, but dreaming was almost five times more common in patients receiving propofol.

Read the abstract of the study in Anesthesia & Analgesia.

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