Study: 5 risk factors for KPC-producing Enterobacteriaceae

A study, published in the Journal of Hospital Infection, examines risk factors for Klebsiella pneumoniae carbapenemase-producing K. pneumoniae colonization and infection among hospitalized patients.

Researchers studied patients with Klebsiella pneumoniae carbapenemase-producing K. pneumoniae, or KPC-Kp, colonization or infection in an Australian hospital. The researchers examined the patients from January 2012 to September 2015.

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They found 34 cases of KPC-producing Enterobacteriaceae, including 31 KPC-Kp cases, and matched these with 136 control cases.

Variables associated with KPC-Kp acquisition included:

•    Length of hospital stay greater than 28 days (within the past year)
•    Prior vancomycin-resistant enterococci colonization
•    Central venous catheter  
•    Gastrointestinal disease and invasive procedures
•    Exposure to broad-spectrum antibiotics

Very few patients had a history of overseas travel, showing that "local screening strategies targeting overseas travelers would likely miss many cases," the study authors concluded.

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