At the University of Louisville (Ky.), researchers are pushing forward with work to deepen scientific understanding regarding the manner by which tobacco smoke increases germ resistance to immune system attacks.
Previous research led by David A. Scott, PhD, associate professor at the Louisville School of Dentistry, revealed that cigarette smoke promoted the formation of biofilms in the oral cavity. Biofilms are composed of multiple, complex microbial communities. Bacterial biofilms can also form on heart valves and the respiratory tract.
"Once a pathogen establishes itself within a biofilm, it can be difficult to eradicate as biofilms provide a physical barrier against the host immune response, can be impermeable to antibiotics and act as a reservoir for persistent infection," said Dr. Scott. "Furthermore, biofilms allow for the transfer of genetic material among the bacterial community and this can lead to antibiotic resistance and the propagation of other virulence factors that promote infection."
Dr. Scott's previous research was published inTobacco Induced Diseases. New research is being calibrated to better understand interactions of communities of biofilms and to help bolster the development of novel treatments.
"We are continuing research to understand the interactions of the elaborate communities within biofilms and how they relate to disease. Many studies have investigated biofilms using single species, but more relevant multispecies models are emerging. Novel treatments for biofilm-induced diseases also are being investigated, but we have a long way to go," said Dr. Scott.
More articles on infection control:
2,200+ contract HIV in India after blood transfusions — 5 things to know
How wireless environmental monitoring minimizes surgical site infection risk
Sepsis mortality in solid organ transplant patients is lower than previously thought