In a study to identify risk factors and outcomes in extended-spectrum beta-lactamose-producing Enterobacteriaceae infections in pediatric patients, researchers found 77 percent of the infections were multi-drug resistant, according to research in the Journal of the Pediatric Infectious Diseases Society.
Researchers examined data on pediatric patients with ESBL-producing Enterobacteriaceae infections from 2008 to 2011. They found 60 percent of the infections occurred in the intensive care unit and 30 percent occurred in outpatient settings. The majority of them, 77 percent, were resistant to at least three antibiotic classes.
Additionally, researchers found ESBL infections were 5.7 times more likely to cause gastrointestinal comorbidities and 3.3 times more likely to cause neurological comorbidities than non-ESBL infection controls.
ESBL infections reoccurred in 17 percent of patients, and both ESBL and controls experienced a 7 percent mortality rate.
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