A study published in Clinical Infectious Diseases examined the dosing and efficacy of an experimental drug RBX2660 for treating Clostridium difficile infections.
Researchers conducted a phase 2B clinical trial that included adult patients with two or more C. diff recurrences. The patients were randomized to receive:
• Two doses of RBX2660 — Group A
• Two doses of placebo — Group B
• One dose of RBX2660 followed by one dose of placebo — Group C
The researchers defined efficacy as prevention of recurrent C. diff for eight weeks following treatment.
The overall efficacy for participants treated with RBX2660 was 88.8 percent.
The study shows the drug efficacy for the groups were as follows:
• Group A: 61 percent
• Group B: 45 percent
• Group C: 67 percent.
Thus, one dose of RBX2660 was found to be superior to placebo. Additionally, the proportion of adverse or serious adverse events did not differ significantly between the groups.