Risk factors of healthcare-associated infections caused by extremely-drug resistant gram-negative bacilli vary by time intervals following initial HAI diagnosis, according to a study in American Journal of Infection Control.
Researchers studied patients between February 2007 and January 2010 in 16 intensive care units to determine risk factors and mortality rates of HAIs attributable to XDR-GNB.
They found risk factors associated with XDR-GNB HAIs include an immunocompromised state and exposure to the antibiotics amikacin, levofloxacin or trimethoprim-sulfamethoxazole.
Researchers evaluated mortality predicators at seven, 15 and 30 days following an HAI diagnosis. Liver disease and immunocompromised states were mortality predictors at all three time intervals. At seven days following diagnosis, bloodstream infections were also mortality predictors, and at 30 days following diagnosis, hospitalization in the ICU became a mortality predictor.
Researchers suggest mortality is associated with liver disease and immunocompromised state, not XDR-GNB HAIs.
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