67% of ICU pathogens are gram-negative

A study, published in the Journal of Antimicrobial Chemotherapy, examines frequency and antimicrobial susceptibility of gram-negative bacteria in intensive care units.

Researchers collected 6,091 bacterial isolates from ICU patients with pneumonia in 75 U.S. medical centers from 2015-17 as part of the International Network for Optimal Resistance Monitoring program.

The study shows gram-negative bacteria were isolated from 67.1 percent of the patients. The most common organisms were:

Staphylococcus aureus: 30 percent
Pseudomonas aeruginosa: 20.7 percent
Klebsiella spp.: 11.8 percent
Enterobacter spp.: 8.3 percent
Escherichia coli: 7.1 percent
Stenotrophomonas maltophilia: 5.1 percent

Colistin, ceftazidime/avibactam and ceftolozane/tazobactam were the most active compounds against P. aeruginosa, while Ceftazidime/avibactam, amikacin and meropenem were the most active compounds against Enterobacteriaceae.

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