A study, published in the Journal of Antimicrobial Chemotherapy, examines frequency and antimicrobial susceptibility of gram-negative bacteria in intensive care units.
Researchers collected 6,091 bacterial isolates from ICU patients with pneumonia in 75 U.S. medical centers from 2015-17 as part of the International Network for Optimal Resistance Monitoring program.
The study shows gram-negative bacteria were isolated from 67.1 percent of the patients. The most common organisms were:
• Staphylococcus aureus: 30 percent
• Pseudomonas aeruginosa: 20.7 percent
• Klebsiella spp.: 11.8 percent
• Enterobacter spp.: 8.3 percent
• Escherichia coli: 7.1 percent
• Stenotrophomonas maltophilia: 5.1 percent
Colistin, ceftazidime/avibactam and ceftolozane/tazobactam were the most active compounds against P. aeruginosa, while Ceftazidime/avibactam, amikacin and meropenem were the most active compounds against Enterobacteriaceae.