Tampa, Fla.-based Moffitt Cancer Center researchers identified an immunosuppressive environment is key to the progression of colorectal cancer development, the center said April 7.
Researchers analyzed interactions between immune cells and cancer cells, including immune blockade, immune suppression and antigenicity. They found precancerous adenomas must pass through a "bottleneck" to progress into malignant carcinomas, which is most frequently accomplished during immunosuppression.
Their findings were published April 4 in Nature Communications.