Antibiotics during hospitalization could increase the risk of sepsis following discharge, according to new study results presented at the IDWeek 2016 meeting in New Orleans, from Oct. 26 to Oct. 30.
Researchers analyzed adult hospitalization and pharmacy data from the Truven Health MarketScan Hospital Drug Database, 2006-2010. They identified a cohort of hospitalized patients and determined subsequent sepsis during a readmission within 90 days after discharge. In all, researchers examined 9.4 million adult patient visits.
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The study found 0.6 percent of patients had sepsis during readmission within 90 days of discharge. Researchers also saw an association between exposure to a high-risk antibiotic during the first hospital visit and a greater sepsis risk during readmission, compared to patients with no antibiotic exposure. Researchers noted high-risk antibiotics had a high likelihood of microbiome disruption.